AYAWANE has one technological platform to develop new chemical entities as well as in vitro and ex vivo biological evaluations for screening and efficacy studies.
Our know-how is divided in three parts :
1-Chemical synthesis :
- New chemical entities synthesis
- Natural or synthetic polymers functionalization
- Polysaccharides experts : hyaluronic acid, dextran, cellulose,...
- Biomaterials/hydrogels elaboration (soluble and insoluble)
- Green chemistry, ecofriendly
2-physicochemical characterization :
- Structural analysis : NMR spectroscopy, infrared spectroscopy,...
- Analytical methods : HPLC, GPC,...
- Electrophoretic properties : agarose gel, acrylamide gel, western blot
- Viscosity measurements
- Stability assays
3-Biological screening :
- Cell cytotoxicity : determination of IC50
- Cell proliferation : determination of ED50
- Cellular adhesion : soluble or coated molecules, biomaterials
- Cellular migration : calibrated scratch assay
- Dermal equivalent (FPLC) : lattice contraction, reorganization
- ELISA assays : growth factors, cytokines, extracellular matrix components
To know more : Watch the services brochure (french)